Fact Sheets/ Alerts

FDA In Brief: FDA requires new warnings for gabapentinoids about risk of respiratory depression (December 2019)

UK Gov. Drug Safety Update: Pregabalin (Lyrica), gabapentin (Neurontin) and risk of abuse and dependence: new scheduling requirements from 1 April (April 2019)

UK Gov.: Pregabalin and gabapentin: proposal to schedule under the Misuse of Drugs Regulations 2001 (February 2017)

NIDA News Release: Can treatment during surgery reduce postoperative opioid use? (December 2017)

Journal Articles

An ethnographic decision model of the initiation of gabapentin misuse among prescription and/or illicit opioid (mis)user (November 2019)

Gabapentin prescribed during substance abuse treatment: The perspective of treatment providers (October 2019)

A study of the reasons for prescribing and misuse of gabapentinoids in prison including their co-prescription with opioids and antidepressants (August 2019)

Reports of gabapentin and pregabalin abuse, misuse, dependence, or overdose: An analysis of the Food And Drug Administration Adverse Events Reporting System (FAERS) (August 2019)

Misuse and Mortality Related to Gabapentin and Pregabalin are Being Under-Estimated: A Two-Year Post-Mortem Population Study (September 2019)

Trends in gabapentin and baclofen exposures reported to U.S. poison centers (July 2019)

Pregabalin and the Risk for Opioid-Related Death: A Nested Case–Control Study (November 2018)

Effect of Perioperative Gabapentin on Postoperative Pain Resolution and Opioid Cessation in a Mixed Surgical Cohort A Randomized Clinical Trial (April 2018)

Gabapentinoid Use in the United States 2002 Through 2015 (February 2018)

Predictors of Gabapentin Overuse With or Without Concomitant Opioids in a Commercially Insured U.S. Population (February 2018)

Treatment of Generalized Anxiety Disorder with Gabapentin (December 2017)

European Neuropsychopharmacology: How addictive are gabapentin and pregabalin? A systematic review (December 2017)

Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case–control study (October 2017)

Risk of neonatal drug withdrawal after intrauterine co-exposure to opioids and psychotropic medications: cohort study (August 2017)

Risk to heroin users of polydrug use of pregabalin or gabapentin (May 2017)

Gabapentin misuse, abuse, and diversion: A systematic review (March 2016)

Gabapentin withdrawal in a depressed patient: A case report (2016)

Other Resources

U.K. Yahoo News: Prescription drugs pregabalin and gabapentin have been reclassified – but it won't stop problem use (April 2019)

New England Cable News (NECN): 'Johnnys': The Latest Killer on the Street (July 2018)

WKYT (Lexington, KY): Spike in number of Gabapentin prescriptions sparks state action (May 2018)

PEW: Abuse of Opioid Alternative Gabapentin Is on the Rise (May 2018)

Louisville Courier Journal: Drug touted as a safe alternative to painkillers has been found in more Louisville deaths (March 2018)

NJ Law Journal: As Opioid Push Continues, NJ Proposes Reporting Requirements for Gabapentin (January 2018)

Pain News Network: Lyrica and Neurontin Use Triples (January 2018)

Charleston Gazette-Mail: As overdoses climb, gabapentin designated 'drug of concern' in WV (December 2017)

PBS: Saving the babies of the opioid epidemic (October 2017)

The National (UAE): Medics see gabapentin overtake tramadol to become number one drug for UAE addicts (October 2017)

Kaiser Health News (KSN): New On The Streets: Drug For Nerve Pain Boosts High For Opioid Abusers (July 2017)

Indy Star: 8,000 pain pills missing from Indiana prison (January 2017)